The normal range for phosphorous is 2.5-4.5 mg/dL. Kidney Failure. But the deficiency does not need to be severe, even lower levels within the normal range may increase the risk [39]. Before joining SelfHacked, she was a research scientist with extensive field and laboratory experience. Heat stroke, hyperthermia (abnormally high body temperature), or fever[, Severe infection (including sepsis, Legionnaires’ disease, and other respiratory infections) [, Tumor-induced softening of bones (oncogenic osteomalacia) [, Genetic disorders, such as X-linked hypophosphatemic rickets [, Bisphosphonates, used to treat osteoporosis, Anemia (due to hemolysis, or the destruction of, Burning or prickling sensation in various parts of the body (paresthesia), Impaired coordination, balance, and speech (Ataxia), Rickets, a disease that weakens the bones in children, A sensation of tingling and numbness (paresthesia). Kidney Failure. Phosphorus is a mineral that combines with other substances to form organic and inorganic phosphate compounds. Monitor blood calcium and phosphate, bone density and growth. This test is ordered to see how much phosphorus is in your blood. Complications may include seizures, coma, rhabdomyolysis, or softening of the bones.. A phosphate test is used to measure the level of phosphate in the blood. As a kid, he suffered from inflammation, brain fog, fatigue, digestive problems, anxiety, depression, and other issues that were poorly understood in both conventional and alternative medicine. In this case, you may experience [13, 27, 7]: Bones are continually being remodeled, undergoing a balanced breakdown and re-building (mineralization). Phosphate, or phosphorus, is required by the body for healthy bones and teeth. A phosphate test measures the amount of phosphate in a blood sample. Too much PTH in the blood can be a sign of a problem. There are 3 main mechanisms that decrease phosphate levels [7]: Phosphate deficiency is linked to various conditions, some of which only impact absorption, while others can affect more than one mechanism. The most common cause is kidney disease, but other conditions can lead to phosphate levels being out of balance. If your phosphorus levels are low, consult with your doctor for a diagnosis and proper treatment. High levels of phosphate can cause itching. Make sure you are eating enough and that your diet is healthy and well balanced. In adults, kidneys will normally get rid of a fairly constant amount of phosphorus (> 90%). High phosphate levels in your blood can increase your risk for serious medical problems and other complications. What are the longer-term implications of hypophosphataemia? Low phosphorus levels in blood are indicative of Hypercalcemia, especially due to hyperparathyroidism, hypothyroidism, chronic antacid use, malnutrition, severe burns, the overuse of diuretics, alcoholism, diabetic ketoacidosis (after treatment) , rickets and osteomalacia (which are due to Vitamin D deficiencies). The parathyroid glands, which lie behind the thyroid, manufacture the parathyroid hormone, which plays a role in regulating your body's levels of the minerals calcium and phosphorus. Both scenarios can be triggered by low phosphate levels [45, 46]. Optimize Your Lab Results to Strengthen Your Immune System! Soft drinks and pre-packaged foods can be high in phosphate content which can cause an imbalance between the calcium and phosphate in the body. In a large study of over 110,000 people, extreme blood phosphate levels – either too high or too low – increased the risk of heart disease (a so-called “U-shaped” relationship). Physicians will run blood tests to check calcium, magnesium, phosphorus and PTH levels in order to make a diagnosis. Increased bone mineralization, on the other hand, attracts phosphorus into the bones and lowers its blood levels [7, 2]. She believes that SelfHacked has the best science that is also layperson-friendly on the web. Regulation of Phosphate. Type 1 and poorly controlled type 2 diabetes. However, many do not use this, because of fear of aluminum toxicity. When phosphate is high in your blood it binds to calcium and causes a chalk like build up in blood vessels and other parts of the body. She spent 4 years reviewing the scientific literature on supplements, lab tests and other areas of health sciences. A phosphate test measures the amount of phosphate in a blood sample. Blood calcium and phosphate levels should be closely monitored. The normal phosphorous levels in the blood … Phosphorus or phosphate high levels may be a sign of kidney disease due to the kidneys are unable to filtrate and excrete the phosphorus excess. Causes shown below are commonly associated with low phosphate levels. Kidney failure may produce high levels of phosphate in the blood 2. Hypercalcemia is a condition in which the calcium level in your blood is above normal. In another study of 79 men, those with high blood pressure had lower phosphate levels than those who were healthy. Phosphorus or phosphate low levels in the blood can be found in case of: An abnormally high phosphorus urine excretion Metabolic syndrome increases the risk of heart disease, stroke, and diabetes [55]. Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists. Drugs to increase phosphate excretion. This site uses Akismet to reduce spam. In another study of 79 men, those with high blood pressure had lower phosphate levels than those who were healthy. A low phosphorus could mean a number of things. higher insulin resistance) [52]. Hypophosphatemia also decreases neutrophil function and platelet survival. In over 42,000 hospitalized patients, blood phosphate levels in the extreme range (high or low) were associated with a greater risk of dying. In over 3,200 kidney disease patients on dialysis, low phosphate levels were associated with dying (from any cause or infection) [58]. Our goal is to not have a single piece of inaccurate information on this website. Your doctor may want you to lower your phosphate levels, which you can do by watching your dietary intake and swapping out certain foods. Phosphorus is an atom, while phosphate is made when phosphorus is bound to oxygen (4 oxygen atoms). The most important thing is to work with your doctor to find out what’s causing your low phosphate and to treat any underlying conditions! Jonathan Ritter, PharmD, PhD (Pharmacology), How to Use Calendula (Marigold) Supplements & DIY Recipes, 8 Proven Vitamin K Benefits + Top Food Sources, The Microbiome: 33 Ways Gut Bacteria Affect Your Body & Mind, Vital for energy metabolism, as the “P” of, Required for muscle contractions and sending out nerve signals, As the most abundant anion (negative ion) in the body, phosphate helps maintain the, Time of the day – levels are lowest in the morning and highest in the evening, Season – higher in the summer than winter, Gender – male children and adolescents have slightly higher levels, Genetics – some genetic mutations affect phosphate absorption in the gut and reabsorption in the kidneys, Long-term malnutrition and replenishment thereafter (the so-called “refeeding syndrome”), when phosphorus-depleted cells siphon all available free phosphate from the blood [, Poor absorption (malabsorption), in conditions such as Crohn’s disease [, Chronic diarrhea, which also lowers gut phosphate absorption [, Hungry bone syndrome, which occurs after correcting hyperparathyroidism and results in an increased bone demand for phosphorus [, Respiratory alkalosis, a condition that occurs when carbon dioxide levels drop too low due to hyperventilation or overbreathing (e.g. Phosphate levels should be monitored in diabetic animals treated with insulin. Your email address will not be published. When kidneys begin to work improperly, waste products and fluids can build up, creating a life-threatening situation. Phosphorus circulates in your bloodstream in the form of phosphate, or PO4, which is the substance measured in the laboratory when your phosphorus level is checked. Patients with high phosphate levels due to dietary intake should speak with a nutritionist to work out a meal plan that will limit high phosphate foods. Having lower-than-normal ALP levels in your blood is rare, but it can indicate malnutrition, which could be caused by celiac disease or a deficiency in certain vitamins and minerals. Hypophosphataemia is usually mild and can often be controlled by diet or lifestyle changes. Hyperphosphatemia is an electrolyte disturbance in which abnormally elevated levels of phosphate are present in the dog's blood. Lower phosphate levels were associated with obesity in both women and men in another study of almost 2,000 people [50]. Drugs that reduce the phosphate … Low phosphate can lead to muscle weakness, which can impact the heart muscle and the muscles needed for breathing. Accordingly, phosphate absorption and reabsorption (in the gut and kidneys, respectively) decline with age [2]. Apart from the obvious – gut, bones, and kidneys – blood phosphate levels are also controlled by the parathyroid gland. To maintain proper biological processes, the body must ingest phosphorus through … Blood and urine levels of phosphate may be off if a person has been taking laxatives or enemas containing sodium phosphate. In particular, high blood phosphorous levels can be a sign of extensive kidney damage. Phosphorus is an important element which is useful for the synthesis of bones and teeth. It is the second most abundant mineral and makes up about 1% of our body weight [1, 2]. Potassium phosphate is used to treat or prevent hypophosphatemia (low blood levels of phosphorus). Save my name, email, and website in this browser for the next time I comment. Phosphate in the bones acts as a buffer that responds to specific imbalances. Hyperphosphatemia is an electrolyte disorder in which there is an elevated level of phosphate in the blood. Medication . Calcium Carbonate tablets - This is the most common medication prescribed for increased blood phosphate levels (hyperphosphatemia). Your nerves and brain cannot function well when phosphate is low. When you panic, you tend to breathe fast and shallow – in other words, you hyperventilate. Blood phosphate comprises a very small part of total body phosphate. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again. Studies have found that low phosphorus weakens the heart, reducing its blood-pumping power. It can occur at any age but is more common in puppies or old dogs with kidney problems. In mild hypophosphatemia, your doctor may prescribe phosphate supplements. There are few medications that may be prescribed for high blood phosphate levels. Severe burns. In a study of almost 13,000 people, high blood phosphate levels were linked to increased mortality . Phosphate levels are usually higher in children than in adults because of the active bone growth occurring in children. Phosphate is a charged particle (ion) that contains the mineral phosphorus. Too much phosphate in the blood is known as hyperphosphatemia. Potassium phosphate is sometimes added to … Phosphorus also helps your nerves and muscles do their jobs. Parathyroid hormone (PTH) blood test: Checks the level of PTH in your blood. Ten to twenty percent of phosphate is excreted via the kidneys which help maintain steady phosphate levels in the blood via tubular reabsorption from urine. Treatment A diet low in phosphate. In some cases, a high phosphate level is due to an overuse of phosphate supplements or eating or drinking foods with high levels of phosphate. Alkaline phosphatase (ALP) is an enzyme that is important for a range of bodily processes. Extra phosphate is filtered by the kidneys and passes out of the body in the urine. The syndrome of post-parturient hypophosphatemia with intravascular hemolytic anemia has been recognized in a few high-producing dairy cows fed low phosphate rations (Grünberg 2014). Treatment involves calcium carbonate and vitamin D supplements to restore mineral balance to the body. In fact, most of the adult skeleton is completely replaced every 10 years or so [32]. Measuring phosphorus levels is a standard part of blood testing. But when the supply is low, kidneys can reabsorb phosphate very efficiently, reducing urine levels down to virtually zero. All of our content is written by scientists and people with a strong science background. Align your health hacks with your genes for optimal health & cognitive function. For instance, the phosphate levels fall when the blood calcium increases. Phosphate is formed in your body when phosphorus combines with oxygen. An ALP test measures how much of this enzyme is circulating in a person’s blood. Your email address will not be published. The terms phosphorus and phosphate are often used interchangeably when talking about testing, but it is the amount of inorganic phosphate in the blood that is measured with a serum phosphorus/phosphate test. There was no significant change in the mean serum calcium, potassium or blood pressure, no patient deteriorated, and six patients were stronger and more alert after the infusion. Low Phosphate Effects . In 56 men, those with the lowest phosphate levels at baseline had the highest number of risk factors associated with metabolic syndrome 20 years later [54]. The treatment of your high blood phosphate levels is to identify the underlying cause, and to treat that condition. What’s more, lower blood phosphate predicted higher blood pressure 20 years later in a study in 56 men [53, 54]. None of these strategies should ever be done in place of what your doctor recommends or prescribes! Phosphorus works together with the mineral calcium to build strong bones and teeth. Treatments for kidney failure includes medications to control blood potassium levels, raise calcium levels and lower phosphate levels 2. Work with your doctor or another health care professional to get an accurate diagnosis. Required fields are marked *. A plus sign next to the number “[1+, 2+, etc...]” means that the information is found within the full scientific study rather than the abstract. A phosphate test measures the amount of phosphate in a blood sample. A high level means too much phosphorus is in your blood. 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