The first of these is DNA repair (Hoeijmakers, 2009). by: pedicatric pandemic. Several examples for typical genotoxic carcinogens will be given. They may have not immediate apparent harmful effects, with cancer developing only after a long latency period. Neoplasia V Carcinogenesis - . They cause damage after repeated or long-duration exposure. • Mutagens have adverse effects on fertility and general reproductive performance. Title: Chemical Carcinogenesis Author: iir Last modified by: Lenovo User Created Date: 2/21/2000 1:27:05 PM Document presentation format: On-screen Show (4:3) – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 749e8f-N2NjZ Formaldehyde is easily detoxified by NH4OH, for example. • All used spill cleanup materials must be treated as hazardous waste. Viral oncogenesis. Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells.The process is characterized by changes at the cellular, genetic, and epigenetic levels and abnormal cell division.Cell division is a physiological process that occurs in almost all tissues and under a variety of circumstances. identify the drug that makes tobacco addictive. • Respirator may be needed for spill cleanup. Key words: cancer stages,carcinogenesis evaluation, chemical carcinogens, chemical carcinogenesis. carcinogens. • Area monitoring may be required in some cases. Examination by a physician, blood tests, etc. Now customize the name of a clipboard to store your clips. What is a carcinogen?. 21. unit 5: diversity of matter. Looks like you’ve clipped this slide to already. CHEMICAL CARCINOGENS. Chemical carcinogens can be mutagens. • Desiccators, plastic boxes, bottle-in-can are acceptable secondary containment. Chemical Carcinogens – Cancer 16 By The Fasting Method. If you continue browsing the site, you agree to the use of cookies on this website. • Regulated areas are usually under negative pressure (fume hood) to contain carcinogens in the hood or room. • All contaminated floor sweepings, debris (paper towels, Kimwipes, plasticware), discarded filters from respirators or vacuums must be bagged, properly labeled and sent out for incineration. • Results of monitoring must be supplied to the employee. Any substance that is capable of causing cancer.Any substance that is capable of causing cancer. • Dry cleaning of surfaces and equipment must be done by vacuum systems with high-efficiency filters. Thorium dioxide Beryllium and compounds Cadmium and compounds Lead and compounds Nickel and compounds Selenium sulfide. Required whenever there is a spill or other emergency. • Records of exposures,. Chemical Carcinogens – workplace risk assessment and health surveillance - . &Carcinogenic Agents. The first stage, initiation, occurs rapidly and appears to be irreversible. • An SOP must contain the following: The name and location of the chemical, purchasing and usage authoriza-tion, training requirements, location of use, PPE required, methods of waste disposal, decontamination, first aid measures, spill control, emergency phone numbers and any other relevant information. it’s a process in which one or more reactants are, Chemical Reactions - . Check “Poison” on the waste label. You can change your ad preferences anytime. Training required. chapter 21: chemical reactions. CTD: a resource for predicting chemical-gene-disease networks - . The … Lab coats need to be cleaned regularly; special washing instructions may be needed. • Cancer is the abnormal or uncontrolled growth of new cells in any part of the body, characterized by cells that tend to invade surrounding tissue and metastasize to new body sites. Chemical carcinogenesis in mouse or rat livers and other organs is known to be prevented or modulated by BHA, bisethylxanthogen, and other antioxidants. GGS Medical College/Baba Farid Univ.of Health Sciences. After cardiovascular diseases, it is the second cause of death amongst the global population (Huff 1994, Weisburger of the work of cco/octrf. Etiology Of Cancer 27 slides: Chemical Carcinogens Carcinogens are chronic toxins. 1. • Remove lab coat or other potentially contaminated protective clothing before leaving the work area. CHEMICAL CARCINOGENSCHEMICAL CARCINOGENS 2. • Employees must be trained in the content of the SOP. How do I reduce my inventory and level of waste generation. Factors governing the outcome include type of exposure, amount of exposure, time of exposure, and genetic makeup of the host (i.e., humans).… • Waste bottles must be properly labeled, tightly capped at all times (except when adding or removing waste) and they must have secondary containment. Hence, polymorphisms of endogenous enzymes such as … Presentation Summary : CHEMICAL CARCINOGENS What is a carcinogen? They include metals such as cobalt and nickel and crystals such as silica. The Styrene Information & Research Center - . • Any substance that is regulated by OSHA as a carcinogen. Create stunning presentation online in just 3 steps. chemical equations. Place no longer needed materials in a recycling program or dispose of as waste. • Protective clothing--lab coats, aprons, Tyvek garments. Related Chemical Safety Training Courses Chemical Protection Clothing Chemical Hygiene and Engineering Chemical Spill Chemical Safety Chemical Handling Chemical Carcinogens by Estonian OH&S Number of Slides:22 Created By:Estonian OH&S This training presentation was created by Estonian OH&S. section 3.2. objectives. Use an “ALARA” policy. • Written emergency response plan. • Training--all employees using carcinogens must be trained in the recognition of the physical and health hazards associated with the carcinogens they are working with, methods to detect the presence or release of a carcinogen and ways to protect themselves from exposure to the carcinogens with which they are working. • Cigarette smoking (co-carcinogen) • Alcohol consumption (co-carcinogen) • Diet--high fat consumption, natural antioxidants • Geographic location--industrial areas, UV light • Therapeutic drugs--some are known carcinogens • Inherited conditions, How do I reduce my exposure to carcinogens? are there differences in the mechanisms of carcinogenesis associated with, Types of Toxicants - . classification based on particular effects on health. • Dry sweeping or compressed air cleaning of floors or work surfaces is prohibited. • All areas where carcinogens may be used, present or stored should have prominently displayed warning signs or labels both in the areas and access to them.. III.C Prevention of Carcinogenesis. How do carcinogens enter the body? • Separated by shelving system or secondary containment. What are reproductive toxins? safety file ... Ionizing radiation Natural products (progesterone, safrole) ... – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 783f26-NjRkM 1988). Direct-acting agents do not require metabolic conversion to become carcinogenic, while indirect-acting agents are not active until converted to an ultimate carcinogen by endogenous metabolic pathways. • Do not allow inventories to accumulate. Which classes of chemicals tend to be carcinogens? • Hundreds of individual compounds have been shown to induce cancers. Common Carcinogens You Should Know. 6. Decontamination and emergency procedures • Safety shower and eyewash station nearby. • It is listed under Group 1 (“carcinogenic to humans”) by the International Agency for Research on Cancer (IARC). overview of carcinogenic agents. ... Tar, which formed up to 1/3 of the chemical of soot, was the chief suspect. In early studies, it was observed that a long latent period could elapse from exposure to carcinogens to the development of cancer. • Carcinogen glove box or environmental chamber. ), Which classes of chemicals tend to be carcinogens? CHEMICAL CARCINOGENS What is a carcinogen? Acknowledgment - . introduction. environmental & occupational carcinogens. • Inhalation. • Storage areas must be labeled “Danger--Carcinogens Stored Here.”. chemical reactions. • Special solutions or solvents on hand if required for decontamination of skin, eyes. organic compounds: Formaldehyde Acetaldehyde 1,4-DioxaneEthyl carbamate 2-Nitropropane Styrene Thiourea Thioacetamide • Misc. A seminal breakthrough was Yamagiwa's production of skin tumors in rabbits by the direct application of coal tar in 1915, which led to the isolation, identification, synthesis, and biological testing of polycyclic aromatic hydrocarbons (PAHs) as chemical carcinogens, including dibenz[a,h]anthracene and … Carcinogen, any of a number of agents that can cause cancer in humans. Chemical Carcinogens Providence Va Medical Center PPT Presentation Summary : CHEMICAL CARCINOGENS What is a carcinogen? What factors influence the development of cancer? The role of metabolic activation in carcinogenesis and the importance of DNA damage and mutation have led to additional avenues of research regarding mechanisms of carcinogenesis and influences on the carcinogenic process. dec 3, 2008. carcinogens : there exists a “measurable” risk from any exposure, eg 4.1 x 10 -6, Chemical Changes - Presented by: bailey newbill. chapter 10. chemical reactions and equations: basic concepts. • Animal studies directly induce cancer in test animals using a large sample of animals, usually of two or more species with varying dose and time parameters. Any substance that … • Specialized training may be required for specific carcinogens. These particles are, in some cases, mined for human use. Administrative controls • Material Safety Data Sheets and other information. Clipping is a handy way to collect important slides you want to go back to later. Cancer is the abnormal or uncontrolled growth of new cells in any part of the body, characterized by cells that tend to invade surrounding tissue and metastasize to new body sites. Regulated areas • Establish regulated or designated areas for the use of carcinogens. Engineering controls--exhaust ventilation and equipment. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Getting cancer from a chemical depends on the following: •The kind of chemical you were exposed to, •How much of the chemical you were in contact with, •How long the contact lasted, •How often you were exposed, eu, CHEMICAL CARCINOGENS - . See our User Agreement and Privacy Policy. Any substance that is capable of causing cancer. 7. • Fume hoods--full open face velocity of 8o to 100 l.f.p.m.. combined with a dry ice capture test. • Mutagens cause damage to chromo-somes by introducing changes to DNA. Swallowing of a carcinogen. • Biosafety cabinet--used for anticancer drugs, viruses. • Plan the use of carcinogens carefully. Their common feature is that their ultimate forms are electrophilic reactants; in most cases, these reactants arise through metabolism in vivo. • Experiments with animals are based on the premise that chemicals that produce cancer in animals will have similar effects on human cells. inorganic comp. View Assignment - Chemical_Carcinogens_1.ppt from OMI 112 at Carville Job Corps Academy. Etiology of Cancer • Chemical carcinogens. • Only authorized persons trained in the use of the carcinogens present may use these areas when such materials are in use. In industry, there are many potential exposures to carcinogens. See section 7.9-11 of the CHP for waste bottle labeling instructions. Chemical carcinogens similarly vary very greatly in potency. Regulation of gene regulation in Eukaryotes, No public clipboards found for this slide, Student at All India Institute of Medical Sciences. • Mutagens are chronic toxins • Teratogens act during pregnancy to cause adverse effects on the embryo or fetus including malformations, retarded growth and post- natal deficiencies. 9. In 1941, Rous and Kidd painted the skin of rabbits and found that if this painting were interrupted, tumors would disappear only to reappear if the application of tar was re-estab… Personnel monitoring with sample pumps or badges. • Lungs • Liver • Kidney • Reproductive system • Skin • Many other organs and tissues, What factors influence the development of cancer? Personal hygiene • No smoking, eating, drinking or application of cosmetics is permitted in areas where carcinogens are in use (or in any lab area!). Training needed. A Right-to-Know (RTK) style label must be on any container of material that is repackaged or made into a solution more than 0.1%. chemical reactions involve a chemical change. Cells constantly deal with the formation of DNA adducts from either endogenous or exogenous influences (Greenfield et al., 1984; Hoeijmakers, 2009; Phillips et al., 2000), including DNA damage that occurs secondary to radiation. • It is listed in either Group 2A (“limited evidence of carcinogenicity” from human studies) or 2B (“sufficient evidence of carcinogenicity” from animal studies) by IARC or under the category “reasonably anticipated to be carcinogens by NTP. See our Privacy Policy and User Agreement for details. Chapter 21: Chemical Reactions - 21. table of contents. • Any “incidental” spill may be cleaned up by the lab staff; larger spills may require a emergency response (5-1111). What dictates this outcome is relatively predictable but highly variable. This may be done by EH&S staff. • Dose--amount and length of exposure. Most chemical carcinogens are mutagens 2. • Local ventilation--exhaust (sometimes supply) at the point of use of a chemical. Most carcinogens, singly or in combination, produce : Vinyl chloride Carbon tetrachloride Chloroform Hexachlorobenzene Trichloroethylene • Hydrazines: Hydrazine (and salts) 1,2-Dimethylhydrazine • N-Nitroso compounds: N-Nitrosodimethylamine • Aromatic Amines: Benzidine Aniline o-Anisidine o-Toluidine • Aromatic hydrocarbons: Benzene Benz[a]anthracene Benzo[a]pyrene, Classes of carcinogens (cont.) INTRODUCTION Public opinion considers cancer to be an increasingly threatening disease, affecting people of all ages. chemical reactions and chemical. 4. 1. carolyn mattingly north carolina state university. • Purchase carcinogens in the smallest possible quantities. monitoring, and medical exams must be kept for 30 years. How is chemical carcinogenicity determined? chemical changes. Any substance that is capable of causing cancer. They may have not immediate apparent harmful effects, with cancer developing only after a long latency period. • Detoxify carcinogens as part of your research protocols. CHEMICAL CARCINOGENS. How do I dispose of waste carcinogens? • Dry wastes must be incinerated or shipped out as regulated medical waste (“chemotheraputic agents”). products. • Hand protection--gloves, protective sleeves. • Asbestos • Certain chemicals • Coal tars and coke oven emissions • Hardwood sawdust (certain species) • Ionizing radiation • Natural products (progesterone, safrole) • Tobacco smoke • Ultraviolet radiation. Personal protective equipment • Respiratory protection--dust masks, respirators. If you continue browsing the site, you agree to the use of cookies on this website. • Epoxides:Ethylene oxide Propylene oxide • Organohalogen comp. Shigeki Tsuchida, in Encyclopedia of Cancer (Second Edition), 2002. How do I reduce my inventory and level of waste generation? Chemical Carcinogens Providence Va Medical Center PPT. • Any discrete chemical compound which has been shown to cause cancer in human or animal studies. • Fire extinguisher at hand as required. © 2020 SlideServe | Powered By DigitalOfficePro, - - - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - - -. chemicals or types of radiation, Chemical Reactions - . 10. How do I reduce my exposure to carcinogens? Cancer is the abnormal or uncontrolled growth of new cells in any Chemical carcinogens may bind to DNA. • Many are commonly used in laboratory operations, shops and art studios. chemical change = chemical reaction a chemical equation is a, 2.6 Chemical Equations - A chemical equation is the symbolic representation of a chemical reaction in terms of chemical. Ionizing Radiation Ionizing radiation includes: X-rays, gamma rays, as well as particulate radiation; alpha, beta, protons, neutrons and primary cosmic radiation. Environmental tobacco smokeEpichlorohydrinEthyl acrylateEthylene dibromideEhtylene dichlorideEthylene oxideEthyleneimineEthylene thioureaFormaldehydeGallium arsenideGasoline The known chemical carcinogens include a wide range of structures. Follo wing exposure, chemical carcinogens may be ab- sorbed in a number of ways (oral, inhalator, cutaneous, and injection) and distributed across several tissues (Con- Breathing gases, fumes and vapors is the most common form of exposure. human carcinogens. Many thousands of additional compounds are “suspect” carcinogens. husni maqboul, m.d. • Any substance that is capable of causing cancer. rachelle heller. Do not make more stock solutions than are required. CHEMICAL CARCINOGENS What is a carcinogen? 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